Director, R&D FP&A
Maze Therapeutics, Inc. · San Francisco Bay Area
📍 South San Francisco, CA💰 $227,000 to $277,000via greenhousePosted 2026-07-21
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The Position
We are seeking a Director, FP& A to serve as a strategic finance partner to our R&D organization . In this highly visible role, you will support critical investment decisions across our development portfolio by delivering financial insights, forecasting, and decision support.
You’ll work closely with R &D and finance leadership to translate scientific and clinical strategies into actionable financial plans, helping ensure resources are deployed effectively across programs.
T his role reports to the Sr. Director of FP&A and follows a hybrid scheduled of two - to- three days per week in office .
The Impact You’ll Have
Strategic Partnership & Decision Support
Partner with R&D leadership and project teams to develop portfolio and program-level financial plans
Lead scenario modeling, cost-benefit analyses, and vendor investment decisions
Support clinical program investment decisions and other high-priority strategic initiatives
Financial Planning & Analysis
Deliver accurate and timely forecasts, budgets, and long-range plans for R&D functions
Prepare and present financial analyses to senior leadership, including materials for Board meetings
Provide variance analysis and actionable insights to inform decision-making
Cross-Functional Collaboration
Partner closely with Accounting to align budget vs actuals, including accruals, coding, and variance reporting
Collaborate with functional stakeholders to translate scientific and operational plans into financial outcomes
Process Improvement & Systems
Drive improvements in FP&A processes, reporting, and forecasting accuracy
Partner with the Head of FP&A to enhance and automate allocation methodologies across programs and indications
As a Director, we also expect our leaders to demonstrate the following Leadership Competencies:
Communication and Influence
Builds communication channels across Maze for sharing information.
Influences Senior Management decisions through persuasive arguments.
Respectfully addresses differing opinions leading to support of decisions.
Teamwork and Collaboration
Champions partnerships and connections across Maze.
Proactively addresses issues that could result in breakdown of team relationships.
Spotlights team and individual contributions in public forums.
Execution and Results
Addresses gaps and leverages strengths to get best results.
Maintains a steadying presence and clarifies priorities during change.
Anticipates and removes barriers that put functional/corporate goals at risk.
Develop Others and Self
Remove barriers to staff development and empowers them to make their own decisions.
Stays current on industry trends and keeps direct-reports prepared and responsive.
What We’re Looking For
Experience & Background
Bachelor’s degree in Finance, Accounting, Economics, or related field; MBA or equivalent experience preferred.
10+ years of experience in the pharmaceutical or biotech industry, including significant FP&A experience
Experience supporting R&D or development organizations strongly preferred
Clinical trial forecasting and accruals experience preferred
Technical & Analytical Skills
Advanced proficiency in Excel and PowerPoint
Experience with financial systems such as NetSuite, Coupa, and Anaplan, or similar tools
Strong financial modeling and forecasting capabilities, including ad hoc analysis
Business Partnership & Communications
Proven ability to build strong relationships and influence cross-functional stakeholders
Ability to translate complex scientific and strategic concepts into clear financial insights
Excellent written and verbal communication
Execution & Mindset
Highly organized with the ability to manage multiple priorities and meet deadlines
Detail-oriented and solution-driven, with a focus on continuous improvement
Collaborative mindset with a focus on improving efficiency and effectiveness
Interest in exploring applications of AI to enhance FP&A processes
This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters two-to-three days per week.
About Maze Therapeutics
Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1 ‑ mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.
Our People
Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution , ultimately, everything we do is about patients.
Our Core Values
Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
Stand True – Our integrity is foundational; it guides us no matter the obstacle.
The expected annual salary range for employees located in the San Francisco Bay Area is
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